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De rares cas de retard de développement chez les enfants de mères épileptiques ont été observés. L'interaction avec le saquinavir / ritonavir n'a pas été étudiée et pourrait être plus marquée! To better evaluate effectiveness the total number of patients experiencing significant improvement (20 degrees or greater) was calculated and compared! Amitriptyline is metabolized in the liver to nortriptyline, which is lipophilic and crosses the blood-brain barrier.
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